Arginine Grafting to Endow Cell Permeability
نویسندگان
چکیده
منابع مشابه
Arginine grafting to endow cell permeability.
We report on a means to endow proteins with the ability to permeate mammalian cells without appending an exogenous domain. Our approach is to install a cationic patch on the surface of a target protein by the grafting of arginine residues. Doing so with GFP did not compromise conformational stability but enabled efficient cellular uptake that was dependent on cell-surface glycosaminoglycans. We...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2007
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb600429k